Human STAT3 Protein, His Tag, low endotoxin (MALS & SPR verified)

Cannot supply to this region.

SKU:: ST3-H5149
Additional Names:: signal transducer and activator of transcription 3|STAT3
Physical State:: Powder
Molecular Weight:: 66.4 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 150 mM NaCl, pH7.5
Immunogen:: STAT3
Species:: Human
Uniprot:: P40763-1
Synonyms:: Acute-phase response factor
Extra Details:: Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes important for essential cellular processes including survival, proliferation, self-renewal, angiogenesis, and immune response. As an early tumor diagnostic marker, it is considered that constitutive STAT3 activation is a sufficient factor to cause malignant transformation and tumor development in model systems. The classical IL-6/STAT3 signaling pathway in cancer cells. IL-6 binds to the membrane-bound IL-6 receptor A Alpha (IL-6R) and IL-6 receptor B Beta (also known as gp130). The IL-6/IL-6R/gp130 complex activate the phosphorylation of JAKs, followed by STAT3 phosphorylation and activation. Then, phosphorylated STAT3 forms a homodimer and translocates into the nucleus to bind to the promotor region of target genes and activates target gene transcription.