Biotinylated SARS-CoV-2 Spike Trimer Protein (T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N), His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: SPN-C82EI
Additional Names:: S glycoprotein|S protein|Spike|Spike glycoprotein
Physical State:: Powder
Molecular Weight:: 139.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 0.1 M Sodium citrate, pH5.5
Immunogen:: Spike protein
Species:: Virus
Extra Details:: Biotinylated SARS-CoV-2 Spike Trimer, His,Avitag (SPN-C82Ei) is the ectodomain of SARS-CoV-2 spike protein which contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). Mutations T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N were identified in the SARS-CoV-2 Delta sub-lineages (Pango lineage: AY.1/AY.2/AY.3; also known as "Delta Plus"). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.