SARS-CoV-2 Spike Trimer Protein (G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N), His Tag (MALS verified)

Cannot supply to this region.

SKU:: SPN-C52HS
Additional Names:: S glycoprotein|S protein|Spike|Spike glycoprotein
Physical State:: Powder
Molecular Weight:: 137.3 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 0.1 M Sodium citrate, pH5.5
Immunogen:: Spike protein
Species:: Virus
Extra Details:: SARS-CoV-2 Spike Trimer, His Tag (SPN-C52Hs) is the ectodomain of SARS-CoV-2 spike protein which contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). Mutations G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N were identified in the SARS-CoV-2 Lambda variant (Pango lineage: C.37). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.