Human SLC7A11&SLC3A2 Full Length Protein, Flag,His Tag (Detergent)

Cannot supply to this region.

SKU:: SLS-H52D3
Physical State:: Liquid
Molecular Weight:: 59.4 kDa & 69.9 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Immunogen:: SLC7A11 & SLC3A2
Species:: Human
Uniprot:: P08195, Q9UPY5
Synonyms:: 4F2;4F2 cell-surface antigen heavy chain;4F2 heavy chain antigen;4F2HC;4T2HC;amino acid transport system xc-;antigen defined by monoclonal antibody 4F2, heavy chain;antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43;calcium channel blocker resistance protein CCBR1;CCBR1;CD98;CD98 heavy chain;CD98HC;cystine/glutamate transporter;lymphocyte activation antigen 4F2 large subunit;MDU1;monoclonal antibody 44D7;NACAE;solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2;solute carrier family 3 (amino acid transporter heavy chain), member 2;Solute carrier family 3 member 2;solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11;Solute carrier family 7 member 11;solute carrier family 7, (cationic amino acid transporter, y+ system) member 11;xCT
Extra Details:: SLC7A11 (xCT) and SLC3A2 (CD98hc) form the heterodimeric system xc- cystine/glutamate antiporter. While SLC7A11 confers transport specificity, SLC3A2 ensures membrane trafficking and stability. This complex maintains redox homeostasis by fueling glutathione synthesis and acts as a critical suppressor of ferroptosis, representing a prime therapeutic vulnerability in oxidative-stress-dependent cancers.

Shipping Conditions:: Dry Ice