Biotinylated Human Siglec-8 Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: SI8-H82E9
Additional Names:: SAF-2|SAF2|Siglec-8|SIGLEC8
Physical State:: Powder
Molecular Weight:: 41.4 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS, 0.5 M Arginine, pH7.4
Immunogen:: Siglec-8
Species:: Human
Uniprot:: Q9NYZ4-1
Synonyms:: Sialoadhesin family member 2
Extra Details:: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.