Human Siglec-2 / CD22 Protein, Llama IgG2b Fc Tag, low endotoxin

Cannot supply to this region.

SKU:: SI2-H525A
Additional Names:: BL-CAM|CD22|SIGLEC-2|SIGLEC2|SIGLEC2FLJ22814
Physical State:: Powder
Molecular Weight:: 103.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: Tris with Glycine, Arginine and NaCl, pH7.5
Immunogen:: Siglec-2
Species:: Human
Uniprot:: P20273-1
Synonyms:: B-lymphocyte cell adhesion molecule;Sialic acid-binding Ig-like lectin 2;T-cell surface antigen Leu-14
Extra Details:: B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.