Biotinylated Human Siglec-10 Protein, His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: SI0-H82E3
Additional Names:: MGC126774|PRO940|SIGLEC10|SLG2
Physical State:: Powder
Molecular Weight:: 61.8 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS with Arginine, pH7.4
Immunogen:: Siglec-10
Species:: Human
Uniprot:: Q96LC7-1
Synonyms:: Siglec-like protein 2
Extra Details:: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.