Biotinylated Cynomolgus Siglec-10 Protein, His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: SI0-C82E5
Physical State:: Powder
Molecular Weight:: 62.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM MES, 150 mM NaCl, 0.5 M Arginine, pH5.0
Immunogen:: Siglec-10
Species:: Non-human Primate
Extra Details:: The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.