SG4-H5223
Human Siglec-14 Protein, His Tag, low endotoxin (MALS verified)
Cannot supply to this region.
- SKU:
- SG4-H5223
- Physical State:
- Powder
- Molecular Weight:
- 39.2 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 20 mM HEPES, 150 mM NaCl, pH7.5
- Immunogen:
- Siglec-14
- Species:
- Human
- Uniprot:
- Q08ET2
- Synonyms:
- sialic acid-binding Ig-like lectin 14;siglec-14
- Extra Details:
- Siglec-14 (Sialic acid-binding ig-like lectin 14) is a type I transmembrane protein mainly expressed on myeloid cells. It forms an activating/inhibitory "paired receptor" pair with the inhibitory receptor Siglec-5. Through an arginine residue in its transmembrane region, Siglec-14 associates with the adaptor protein DAP12. Upon activation, the ITAM motif of DAP12 recruits Syk kinase and initiates pro-inflammatory signaling. A functional null polymorphism of the SIGLEC14 gene exists in human populations; this loss of function is associated with reduced risk of acute exacerbation of chronic obstructive pulmonary disease (COPD) and decreased susceptibility to tuberculous meningitis. Siglec-14 plays important regulatory roles in pathogen recognition and tumor immunity.
- Shipping Conditions:
- Ambient