Mouse ROR1 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: RO1-M5221
Additional Names:: NTRKR1|ROR1
Physical State:: Powder
Molecular Weight:: 42.9 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: ROR1
Species:: Mouse
Uniprot:: Q9Z139
Synonyms:: 2810404D04Rik;inactive tyrosine-protein kinase transmembrane receptor ROR1;neurotrophic tyrosine kinase, receptor-related 1;Ntr;Ntrkr1;tyrosine-protein kinase transmembrane receptor ROR1
Extra Details:: Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1E Epsilon) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.