Biotinylated Rat TNFSF11 / RANKL / CD254 Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: RAL-R82Q9
Additional Names:: CD254|ODF|OPGL|RANKL|TRANCE
Physical State:: Powder
Molecular Weight:: 31.8 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: TNFSF11
Species:: Rat
Uniprot:: Q9ESE2-1
Synonyms:: Osteoclast differentiation factor;Osteoprotegerin ligand;Receptor activator of nuclear factor kappa-B ligand;TNF-related activation-induced cytokine
Extra Details:: Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.