Human Nectin-3 / CD113 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: PV3-H52E4
Additional Names:: CD113|Nectin-3|PVRL3
Physical State:: Powder
Molecular Weight:: 39.6 kda
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Nectin-3
Species:: Human
Uniprot:: Q9NQS3
Synonyms:: CD113;CDW113;nectin 3;Nectin cell adhesion molecule 3;nectin-3;poliovirus receptor-related 3;poliovirus receptor-related protein 3;PPR3;PRR3;PVRL3;PVRR3
Extra Details:: Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.