Human PTP4A3 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: PT3-H5143
Physical State:: Powder
Molecular Weight:: 21.1 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS, 0.2 M Arginine, pH7.4
Immunogen:: PTP4A3
Species:: Human
Uniprot:: O75365
Synonyms:: phosphatase of regenerating liver 3;potentially prenylated protein tyrosine phosphatase;PRL-3;PRL-R;PRL3;protein tyrosine phosphatase type IVA 3;protein tyrosine phosphatase type IVA, member 3;Protein-tyrosine phosphatase 4a3;protein-tyrosine phosphatase of regenerating liver 3
Extra Details:: PTP4A3 (Protein Tyrosine Phosphatase 4A3) is an oncogenic phosphatase that promotes tumor metastasis by enhancing cell migration, invasion, and survival. It is overexpressed in multiple cancers (e.g., breast, ovarian, colorectal) and correlates with poor prognosis. PTP4A3 activates Rho GTPases and downstream pathways (ROCK/LIMK/cofilin) to remodel the actin cytoskeleton, facilitating cancer cell dissemination. Its dual cysteine-based catalytic domain dephosphorylates key signaling proteins, driving aggressive phenotypes. Targeting PTP4A3 offers therapeutic potential for inhibiting metastasis.