Biotinylated Cynomolgus PSMA / FOLH1 Protein, His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: PSA-C82Q6
Physical State:: Powder
Molecular Weight:: 83.1 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 25 mM MES, 500 mM NaCl, pH6.5
Immunogen:: PSMA
Species:: Non-human Primate
Uniprot:: A0A2K5VNZ0
Synonyms:: folate hydrolase 1B;putative N-acetylated-alpha-linked acidic dipeptidase
Extra Details:: Prostate-specific membrane antigen (PSMA) is also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1), which belongs to the peptidase M28 family and M28B subfamily. FOLH1 / PSMA is stable at pH greater than 6.5. FOLH1 / PSMA is a type II transmembrane zinc metallopeptidase that is most highly expressed in the nervous system, prostate, kidney, and small intestine. FOLH1 / GCP-2 is homodimer and binds 2 zinc ions per subunit, and required for NAALADase activity. The catalytic activity of PSMA involved in releasing of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly - gamma - glutamates. FOLH1 / GCP-2 / PSMA has both folate hydrolase and N - acetylated - alpha - linked - acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. GCP-2 / PSMA involved in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.