PS3-H5142
Human PSME3 / PA28g Protein, His Tag
Cannot supply to this region.
- SKU:
- PS3-H5142
- Additional Names:
- PA28gamma|PSME3|REG-gamma
- Physical State:
- Powder
- Molecular Weight:
- 30.3 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH7.5
- Immunogen:
- PSME3
- Species:
- Human
- Uniprot:
- P61289-1
- Synonyms:
- 11S regulator complex subunit gamma;Activator of multicatalytic protease subunit 3;Ki nuclear autoantigen;Proteasome activator 28 subunit gamma
- Extra Details:
- Proteasome activator complex subunit 3 (PSME3),a member of the PA28 family, is also known as 11S regulator complex subunit gamma (REG-gamma), activator of multicatalytic protease subunit 3 and proteasome activator 28 subunit gamma (PA28gamma). PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSME3 can also facilitate the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Furthermore,PSME3 may also be involved in cell cycle regulation.
- Shipping Conditions:
- Ambient