Biotinylated Human PSGL-1 / CD162 Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: PS1-H82E4
Additional Names:: CD162|PSGL1|Selectin P ligand|SELPLG
Physical State:: Powder
Molecular Weight:: 32.4 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: PSGL-1
Species:: Human
Uniprot:: Q14242-1
Synonyms:: Selectin P ligand
Extra Details:: P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162. PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 / SELPLG interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Dimerization appears not to be required for P-selectin/SELP binding. PSGL-1 can interact with SNX20, MSN and SYK. PSGL-1 / SELPLG mediate the activation of SYK by SELPLG.