Human Prolactin R / PRLR Protein, His Tag

Cannot supply to this region.

SKU:: PRR-H52HA
Additional Names:: PRL-R|PRLR|Prolactin R
Physical State:: Powder
Molecular Weight:: 26.3 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 150 mM NaCl, pH7.5
Immunogen:: Prolactin R
Species:: Human
Uniprot:: P16471-1
Extra Details:: As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.