PR5-H55D3
Human PRMT5 & MEP50 Protein, Flag,His Tag (MALS verified)
Cannot supply to this region.
- SKU:
- PR5-H55D3
- Physical State:
- Liquid
- Molecular Weight:
- 74.4 kDa & 38.3 kDa
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 500 mM NaCl, pH7.5
- Immunogen:
- PRMT5 & MEP50
- Species:
- Human
- Uniprot:
- O14744-1, Q9BQA1
- Synonyms:
- 72 kDa ICln-binding protein;androgen receptor cofactor p44;Histone-arginine N-methyltransferase PRMT5;HKMT1069;Jak-binding protein 1;MEP-50;MEP50;methylosome protein 50;Nbla10071;p44;p44/Mep50;Shk1 kinase-binding protein 1 homolog;testis tissue sperm-binding protein Li 44a;WD repeat-containing protein 77
- Extra Details:
- Protein arginine methyltransferase 5 (PRMT5) is a type II enzyme that catalyzes symmetric dimethylation of arginine residues on histone and non-histone proteins. It forms a hetero-octameric complex with its essential cofactor MEP50 (methylosome protein 50), which enhances its catalytic activity and substrate selectivity. The PRMT5-MEP50 complex regulates gene expression epigenetically, influences RNA splicing, and modulates signal transduction pathways. Aberrant PRMT5-MEP50 activity is linked to tumorigenesis, cardiovascular disorders, and neurodegeneration by driving dysregulated methylation patterns that favor cell proliferation and survival.
- Shipping Conditions:
- Dry Ice