Human pIgR Protein, His Tag

Cannot supply to this region.

SKU:: PIR-H5222
Additional Names:: PIGR|Poly-Ig receptor
Physical State:: Powder
Molecular Weight:: 68.7 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: pIgR
Species:: Human
Extra Details:: Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC). PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.