Human Progranulin Protein, His Tag, low endotoxin (MALS & SPR verified)

Cannot supply to this region.

SKU:: PGN-H52H3
Physical State:: Powder
Molecular Weight:: 63.7 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Progranulin
Species:: Human
Uniprot:: P28799-1
Synonyms:: Proepithelin
Extra Details:: Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene. Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 cysteine granulin motif. Many cellular processes and diseases are associated with this unique pleiotropic factor that include, but are not limited to, embryogenesis, tumorigenesis, inflammation, wound repair, neurodegeneration and lysosome function. Haploinsufficiency caused by autosomal dominant mutations within the GRN gene leads to frontotemporal lobar degeneration, a progressive neuronal atrophy that presents in patients as frontotemporal dementia.