Human Perlecan Protein, His Tag, low endotoxin

Cannot supply to this region.

SKU:: PEN-H5245
Physical State:: Powder
Molecular Weight:: 12.2 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Perlecan
Species:: Human
Uniprot:: P98160
Synonyms:: basement membrane-specific heparan sulfate proteoglycan core protein;endorepellin (domain V region);HSPG;Perlecan;perlecan proteoglycan;PLC;PRCAN;SJA;SJS;SJS1
Extra Details:: Siglec-15 is a transmembrane glycoprotein belonging to the Siglec family, recognized for its sialic acid-binding properties and role in immune regulation. Structurally, its extracellular domain contains two Ig-like domains, and it functionally associates with the signaling adaptors DAP12 and DAP10. Siglec-15 is expressed on immune cells, including osteoclasts, macrophages, and dendritic cells. It exerts its function by binding to its ligand, the sialyl-Tn antigen. This interaction is critical for inducing TGF-beta production by tumor-associated macrophages and plays an essential role in osteoclast formation and TRANCE/RANK Ligand signaling.