Human PDE4A Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: PDA-H55H3
Physical State:: Liquid
Molecular Weight:: 47.1 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: 50 mM Tris, 150 mM NaCl, pH7.5
Immunogen:: PDE4A
Species:: Human
Uniprot:: P27815-1
Synonyms:: DPDE2;PDE46
Extra Details:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A) is an enzyme that in humans is encoded by the PDE4A gene. It belongs to the PDE family who hydrolyze 3'-5'-cyclic adenosine monophosphate (cyclic AMP) to 5'-adenosine monophosphate (AMP). PDE enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as in various neurologic, dermatological, and inflammatory diseases.