Human PD-1 Protein, His Tag (Nanoparticle)

Cannot supply to this region.

SKU:: PD1-H52H2
Additional Names:: CD279|PD1|PDCD1|SLEB2
Physical State:: Powder
Molecular Weight:: 47.1 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS with glycine and sodium citrate, pH8.0
Immunogen:: PD-1
Species:: Human
Uniprot:: Q15116-1
Extra Details:: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-G Gamma. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-G Gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-G Gamma secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.