Hamster PCSK9 Protein, His Tag

Cannot supply to this region.

SKU:: PC9-H52E4
Additional Names:: FH3|HCHOLA3|LDLCQ1|NARC1|PC9|PCSK9
Physical State:: Powder
Molecular Weight:: 13.9 kDa and 59.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: PCSK9
Species:: Hamster
Uniprot:: G3GTK5
Synonyms:: Proprotein convertase 9;Subtilisin/kexin-like protease PC9
Extra Details:: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).