Biotinylated Cynomolgus PCSK9 Protein, His,Avitag[TM] (MALS verified)

Cannot supply to this region.

SKU:: PC9-C82E3
Physical State:: Powder
Molecular Weight:: 75.1 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: PCSK9
Species:: Non-human Primate
Uniprot:: A8T666
Synonyms:: PC9;proprotein convertase 9;proprotein convertase PC9;proprotein convertase subtilisin/kexin type 9;proprotein convertase subtilisin/kexin type 9 preproprotein;subtilisin/kexin-like protease PC9
Extra Details:: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).