Biotinylated Human Osteopontin (OPN) Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: OPN-H82E8
Additional Names:: BNSP|BSP-1|BSPI|ETA-1|Nephropontin|OPN|Osteopontin|SPP1|Uropontin
Physical State:: Powder
Molecular Weight:: 35.7 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: Osteopontin
Species:: Human
Uniprot:: P10451-5
Synonyms:: Bone sialoprotein 1;Nephropontin;Secreted phosphoprotein 1;Urinary stone protein;Uropontin
Extra Details:: Osteopontin (OPN) is also known as Secreted phosphoprotein 1 (SPP1), Bone sialoprotein 1, Nephropontin, Urinary stone protein, Uropontin, BNSP, which belongs to the osteopontin family. OPN / SPP1 is a highly negatively charged, extracellular matrix protein that lacks an extensive secondary structure. Full length OPN (OPN-FL) can be modified by thrombin cleavage, which exposes a cryptic sequence, SVVYGLR on the cleaved form of the protein known as OPN-R. Osteopontin / SPP-1 is biosynthesized by a variety of tissue types. OPN is the ligand for integrin alpha-V/beta-3. OPN / SPP1 binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix. OPN / SPP1 probably important to cell-matrix interaction. OPN / SPP1 acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.