NYZ-H52D4
Human NY-ESO-1 TCR & CD3E & CD3D & CD3G & CD3Z Full Length Protein Complex, His Tag&Flag Tag (Detergent)
Cannot supply to this region.
- SKU:
- NYZ-H52D4
- Physical State:
- Liquid
- Molecular Weight:
- 64.8 kDa & 80.2 kDa
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM HEPES, 150 mM NaCl, 0.06% Buffer A, pH7.5
- Immunogen:
- NY-ESO-1 TCR & CD3E & CD3D & CD3G & CD3Z
- Species:
- Human
- Uniprot:
- P04234-1, P07766-1, P09693-1, P20963-1
- Synonyms:
- T-cell receptor T3 delta chain;T-cell receptor T3 gamma chain;T-cell receptor T3 zeta chain;T-cell surface antigen T3/Leu-4 epsilon chain
- Extra Details:
- Cluster of Differentiation 3 (CD3) is a pivotal multimeric T cell co-receptor complex essential for adaptive immune responses. Composed of epsilon (E Epsilon), gamma (G Gamma), delta (D Delta), and zeta (Z Zeta) polypeptide chains forming three distinct dimers (E EpsilonG Gamma, E EpsilonD Delta, Z ZetaZ Zeta), CD3 non-covalently associates with the T-cell receptor (TCR) to establish the critical TCR/CD3 receptor complex on T cell surfaces. Structurally, CD3 proteins belong to the immunoglobulin superfamily, featuring a transmembrane domain, an N-terminal extracellular region with immunoglobulin-like domains, and cytoplasmic tails embedded with immunoreceptor tyrosine-based activation motifs (ITAMs). These ITAMs are fundamental for initiating signal transduction upon T cell receptor engagement, thereby activating both CD4+ T helper and CD8+ cytotoxic T cells. As a defining marker of the T cell lineage, CD3's central role in T cell activation makes its modulation, via stimulating or blocking antibodies, a promising therapeutic avenue for conditions like organ transplant rejection and autoimmune diseases.
- Shipping Conditions:
- Dry Ice