Human Nr4a1 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: NR1-H5144
Physical State:: Powder
Molecular Weight:: 29.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS, 0.2 M Arginine, pH7.4
Immunogen:: Nr4a1
Species:: Human
Uniprot:: P22736-1
Synonyms:: Early response protein NAK1;Nuclear hormone receptor NUR/77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3
Extra Details:: Orphan nuclear receptor 4A1(NR4A1) belongs to the NR4A superfamily and plays an important role in inflammation, cell metabolism, proliferation and differentiation. NR4A1 expression can be induced by various stimuli in macrophages. NR4A1 has a bidirectional effect of inhibiting or promoting the inflammatory response of atherosclerosis (AS), which may be related to the different microenvironment, cell phenotype and transfection vector. NR4A1 can promote pathological angiogenesis, which is an important factor affecting plaque instability. The role of NR4A1 in inflammation and pathological angiogenesis of AS was reviewed, in order to provide a target for the treatment of stable plaque and provide a reference for the prevention and treatment of AS.