Human NOTCH2 Protein, Fc Tag (MALS verified)

Cannot supply to this region.

SKU:: NO2-H5255
Additional Names:: hN2|N2ECD|NOTCH2
Physical State:: Powder
Molecular Weight:: 80.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: NOTCH2
Species:: Human
Uniprot:: Q04721-1
Extra Details:: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .