Cynomolgus MMP-7 Protein, His Tag (Pro-form, HPLC verified)

Cannot supply to this region.

SKU:: MM7-C53H3
Physical State:: Liquid
Molecular Weight:: 29.9 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: 10 mM HEPES, 150 mM NaCl, pH7.5
Immunogen:: MMP-7
Species:: Non-human Primate
Uniprot:: G7PNJ9
Extra Details:: MMP-7 (matrilysin), the smallest zinc-dependent endopeptidase in the MMP family, lacks a hemopexin domain but features a catalytic zinc-binding motif (HEXXHXXGXXH) critical for degrading extracellular matrix (ECM) components, including collagens III/IV/V, elastin, and proteoglycans. Activated via proteolytic cleavage (e.g., by MMP-3), it promotes tissue remodeling in wound healing while driving pathological processes such as tumor invasion (via E-cadherin degradation and Wnt/B Beta-catenin activation) and fibrosis (via B Beta-catenin-mediated renal damage). Overexpressed in epithelial cancers, MMP-7 correlates with metastasis but paradoxically shows protective genetic variants in some contexts. It also processes non-ECM substrates like TNF-A Alpha and Fas ligand, amplifying inflammation and oncogenesis. In fibrotic diseases, elevated serum MMP-7 predicts progression, serving as a diagnostic biomarker. Therapeutic strategies targeting MMP-7, including inhibitors and monoclonal antibodies, highlight its dual roles as both a driver of ECM disruption and a modulator of immune-tumor interactions.