Mouse MARCO Protein, His Tag

Cannot supply to this region.

SKU:: MAR-M5245
Additional Names:: Macrophage receptor with collagenous structure|MARCO|SCARA2|Scavenger receptor class A member 2
Physical State:: Powder
Molecular Weight:: 47.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: PBS
Immunogen:: MARCO
Species:: Mouse
Uniprot:: Q60754-1
Synonyms:: Macrophage receptor with collagenous structure
Extra Details:: MARCO is also known as Scavenger receptor class A member 2 and SCARA2. Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2. MARCO ligation promotes the production of inflammatory mediators by macrophages. MARCO mediated internalization of some ligands prevents their activation of cell surface TLR4 but enables their activation of intracellular TLR3. MARCO contributes to the clearance of apoptotic cells and inhaled bacteria, mast cell mediated silicosis, and the amelioration of allergen or ozone induced lung inflammation. It is required for the organization of the splenic marginal zone and the interaction of splenic macrophages and B cells.