Human MAdCAM-1 Protein, Fc Tag, low endotoxin (MALS verified)

Cannot supply to this region.

SKU:: MAM-H5253
Additional Names:: MAdCAM-1|Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1
Physical State:: Powder
Molecular Weight:: 59.6 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: MAdCAM-1
Species:: Human
Uniprot:: Q4PKD0-1
Extra Details:: The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the A Alpha4B Beta7 integrin expressed on lymphocytes.