Human MANF Protein, His Tag, low endotoxin (MALS verified)

Cannot supply to this region.

SKU:: MAF-H52H3
Physical State:: Powder
Molecular Weight:: 20.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: MANF
Species:: Human
Uniprot:: P55145
Synonyms:: Arginine-rich protein;arginine-rich, mutated in early stage tumors;ARMET;ARP;mesencephalic astrocyte-derived neurotrophic factor;Protein ARMET
Extra Details:: MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF and its structural homolog CDNF each contain a N-terminal, saposin-like, lipid-binding domain, and a carboxyl-terminal domain that is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues.