Human Matriptase / ST14 Catalytic Domain Protein, His Tag (active enzyme)

Cannot supply to this region.

SKU:: MAE-H5143
Physical State:: Liquid
Molecular Weight:: 30.6 kDa
Storage Conditions:: -70[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 150 mM NaCl, Trehalose, pH7.5
Immunogen:: Matriptase
Species:: Human
Extra Details:: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing; Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.