Mouse LY75 / CD205 Protein, His Tag (MALS verified)

Cannot supply to this region.

SKU:: LY5-M52H5
Additional Names:: CD205|CLEC13B|DEC-205|gp200-MR6|LY75|Lymphocyte antigen 75
Physical State:: Powder
Molecular Weight:: 190.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: LY75
Species:: Mouse
Uniprot:: Q60767-1
Synonyms:: DEC-205
Extra Details:: lymphocyte antigen 75 (Ly 75, also known as CD205, CLEC13B, GP200-MR6 and DEC-205, is a type I transmembrane protein that is primarily expressed on dendritic cells and thymic epithelial cells. LY75 functions as an endocytic receptor for antigens. MEN1309/OBT076, the first antibody drug targeting CD205, has shown strong preclinical anti-tumor activity in lymphoma. After being verified as a single drug in vivo, the antibody-drug conjugate has a synergistic effect with the BCL2 inhibitor Venetoclax and the anti-cd20 monoclonal antibody rituximab.