Biotinylated Human LRP-6 (20-630) Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: LR6-H82E7
Additional Names:: LRP-6|LRP6
Physical State:: Powder
Molecular Weight:: 72.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: LRP-6
Species:: Human
Uniprot:: O75581-1
Extra Details:: LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.