LR6-H5253
Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag
Cannot supply to this region.
- SKU:
- LR6-H5253
- Additional Names:
- LRP-6|LRP6
- Physical State:
- Powder
- Molecular Weight:
- 95.8 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- Tris with Glycine, Arginine and NaCl, pH7.5
- Immunogen:
- LRP-6
- Species:
- Human
- Uniprot:
- O75581-1
- Extra Details:
- LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.
- Shipping Conditions:
- Ambient