Human LGR5 / GPR49 Protein, His Tag, low endotoxin

Cannot supply to this region.

SKU:: LG5-H52H3
Additional Names:: G-protein coupled receptor 49|G-protein coupled receptor 67|G-protein coupled receptor HG38|GPR49|GPR67|Leucine-rich repeat-containing G-protein coupled receptor 5|LGR5
Physical State:: Powder
Molecular Weight:: 62.0 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: LGR5
Species:: Human
Uniprot:: O75473-1
Synonyms:: G-protein coupled receptor 49;G-protein coupled receptor 67;G-protein coupled receptor HG38
Extra Details:: LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/B Beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.