LA5-H52H9
Human LAMP5 / BAD-LAMP Protein, His Tag
Cannot supply to this region.
- SKU:
- LA5-H52H9
- Additional Names:
- BAD-LAMP|Brain and dendritic cell-associated LAMP|LAMP5
- Physical State:
- Powder
- Molecular Weight:
- 25 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- PBS
- Immunogen:
- LAMP5
- Species:
- Human
- Uniprot:
- Q9UJQ1-1
- Synonyms:
- Brain and dendritic cell-associated LAMP;Brain-associated LAMP-like protein;Lysosome-associated membrane protein 5
- Extra Details:
- LAMPs (lysosome associated membrane proteins) represent a family of glycosylated proteins present predominantly on the membrane of lysosomes whose expression can vary among different tissues, suggesting a separation of functions. LAMP5 is expressed highly and specifically in MLL-r leukemia. LAMP5 is a direct target of the oncogenic MLL-fusion protein. LAMP5 depletion significantly inhibited leukemia cell growth in vitro and in vivo. Functional studies showed that LAMP-5 is a novel modulator of innateimmune pathways in MLL-r leukemias. Downregulation of LAMP5 led to inhibition of NF-K KappaB signaling and increased activation of type-1 interferon signaling downstream of Toll-like Receptor/Interleukin 1 Receptor activation.
- Shipping Conditions:
- Ambient