Human KRAS Protein, His Tag

Cannot supply to this region.

SKU:: KRS-H5547
Additional Names:: c-K-ras|c-Ki-ras|CFC2|GTPase Kras|K-Ras 2|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|Ki-Ras|KRAS|KRAS1|KRAS2|NS|NS3|RASK2
Physical State:: Powder
Molecular Weight:: 21.3 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: 50 mM Tris, 0.5 M NaCl, pH7.5
Immunogen:: KRAS
Species:: Human
Uniprot:: P01116-2
Synonyms:: c-K-ras;c-Ki-ras;K-Ras 2;Ki-Ras
Extra Details:: KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) gene is a proto-oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is also known as Ki-Ras, c-K-ras and c-Ki-ras. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation, promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. RAS is one of the most frequently mutated oncogenes in human cancer but the frequency and distribution of RAS gene mutations are not uniform. In details, mutation of glycine 12 (G12) causes RAS activation by interfering with GAP binding and GAP-stimulated GTP hydrolysis. The reference shows the pathway may as a potential therapy targets.