Biotinylated Human KREMEN2 Protein, His,Avitag[TM]

Cannot supply to this region.

SKU:: KR2-H82E8
Physical State:: Powder
Molecular Weight:: 18.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
ABP:: No Import Docs
Buffer:: 0.2 M Arginine, PBS, pH7.4
Immunogen:: KREMEN2
Species:: Human
Uniprot:: Q8NCW0-1
Synonyms:: Dickkopf receptor 2;Kringle domain-containing transmembrane protein 2;Kringle-containing protein marking the eye and the nose
Extra Details:: Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/B Beta-catenin signaling pathway. Krm1 and its paralog Krm2 share the ability to bind Dkk1 and inhibit Wnt signaling, both processes previously shown to rely on the extracellular domain. Previous studies have shown that Krm2 may be involved in embryonic development, bone formation, neural ridge formation and tumorigenesis and could be a biomarker of grading and a potential therapeutic target in gastric cancer.