KL1-H5249
Human KLRG1 Protein, His Tag
Cannot supply to this region.
- SKU:
- KL1-H5249
- Additional Names:
- KLRG1
- Physical State:
- Powder
- Molecular Weight:
- 17.4 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- ABP:
- No Import Docs
- Buffer:
- PBS
- Immunogen:
- KLRG1
- Species:
- Human
- Uniprot:
- Q96E93-1
- Synonyms:
- C-type lectin domain family 15 member A;ITIM-containing receptor MAFA-L;MAFA-like receptor;Mast cell function-associated antigen
- Extra Details:
- The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.
- Shipping Conditions:
- Ambient