Biotinylated Cynomolgus KLRG1 Protein, Avitag[TM],His Tag

Cannot supply to this region.

SKU:: KL1-C82Q4
Physical State:: Powder
Molecular Weight:: 18.5 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: PBS
Immunogen:: KLRG1
Species:: Non-human Primate
Uniprot:: A0A2K5WAP9
Extra Details:: The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.