KL1-C5269
Cynomolgus KLRG1 Protein, Fc Tag (SPR verified)
Cannot supply to this region.
- SKU:
- KL1-C5269
- Physical State:
- Powder
- Molecular Weight:
- 41.3 kda
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
- Immunogen:
- KLRG1
- Species:
- Non-human Primate
- Uniprot:
- A0A2K5WAP9
- Extra Details:
- The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.
- Shipping Conditions:
- Ambient