KI4-H5255
Human KIR2DL4 / CD158d Protein, Fc Tag
Cannot supply to this region.
- SKU:
- KI4-H5255
- Additional Names:
- CD158d
- Physical State:
- Powder
- Molecular Weight:
- 50.5 kDa
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
- Immunogen:
- KIR2DL4
- Species:
- Human
- Uniprot:
- Q99706-1
- Synonyms:
- CD158 antigen-like family member D;G9P;Killer cell inhibitory receptor 103AS;MHC class I NK cell receptor KIR103AS
- Extra Details:
- Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit)-AKT-NF-K KappaB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and SHP-2, and the following inhibition of CD16/FcG GammaRIIIa signaling pathway in human NK cells.
- Shipping Conditions:
- Ambient