Human Integrin alpha E beta 7 (ITGAE&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)

Cannot supply to this region.

SKU:: IT7-H52W7
Additional Names:: Integrin alpha E beta 7|ITGAE&ITGB7
Physical State:: Powder
Molecular Weight:: 128.6 kDa (ITGAE) & 81.8 kDa (ITGB7)
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 150 mM NaCl, pH7.5
Immunogen:: Integrin alpha E beta 7
Species:: Human
Uniprot:: P26010-1, P38570-1
Synonyms:: Gut homing receptor beta subunit;HML-1 antigen;Integrin alpha-IEL;Mucosal lymphocyte 1 antigen
Extra Details:: Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues. This is a strikingly narrow pattern of expression compared with that of other integrins. Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body. The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7). This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.