IT7-H52W4
Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS & SPR verified)
Cannot supply to this region.
- SKU:
- IT7-H52W4
- Additional Names:
- Integrin alpha 4 beta 7|ITGA4&ITGB7
- Physical State:
- Powder
- Molecular Weight:
- 111.4 kDa (ITGA4) & 83.7 kDa (ITGB7)
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 150 mM NaCl, 0.2 M Arginine, pH7.5
- Immunogen:
- Integrin alpha 4 beta 7
- Species:
- Human
- Uniprot:
- P13612-1, P26010-1
- Synonyms:
- CD49 antigen-like family member D;Gut homing receptor beta subunit;Integrin alpha-IV;VLA-4 subunit alpha
- Extra Details:
- Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer's patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
- Shipping Conditions:
- Ambient