IT6-M52W9
Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified)
Cannot supply to this region.
- SKU:
- IT6-M52W9
- Additional Names:
- Integrin alpha V beta 6|ITGAV&ITGB6
- Physical State:
- Powder
- Molecular Weight:
- 112.5 kDa (ITGAV) & 80.2 kDa (ITGB6)
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH7.5
- Immunogen:
- Integrin alpha V beta 6
- Species:
- Mouse
- Uniprot:
- P43406-1, Q9Z0T9-1
- Synonyms:
- Vitronectin receptor subunit alpha
- Extra Details:
- Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency-associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
- Shipping Conditions:
- Ambient