Biotinylated Mouse Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His,Avitag[TM]&Tag Free

Cannot supply to this region.

SKU:: IT5-M82W9
Additional Names:: Integrin alpha V beta 5|ITGAV&ITGB5
Physical State:: Powder
Molecular Weight:: 114.2 kDa | 81.8 kDa
Storage Conditions:: -20[o]C
Supplier:: ACRO Biosystems
Buffer:: 50 mM Tris, 150 mM NaCl, pH7.5
Immunogen:: Integrin alpha V beta 5
Species:: Mouse
Uniprot:: O70309-1, P43406-1
Synonyms:: Vitronectin receptor subunit alpha
Extra Details:: Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.