IT3-H52W8
Human Integrin alpha 2b beta 3 (ITGAIIb&ITGB3) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
Cannot supply to this region.
- SKU:
- IT3-H52W8
- Additional Names:
- Integrin alpha 2b beta 3|ITGAIIb&ITGB3
- Physical State:
- Powder
- Molecular Weight:
- 111.4 kDa (ITGAIIb) & 81.8 kDa (ITGB3)
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH7.5
- Immunogen:
- Integrin alpha 2b beta 3
- Species:
- Human
- Uniprot:
- P05106-1, P08514-1
- Synonyms:
- GPalpha IIb;Platelet membrane glycoprotein IIb;Platelet membrane glycoprotein IIIa
- Extra Details:
- Integrin alpha IIb beta 3 exist in a conformational equilibrium clustered around four main states. These conformations range from a compact bent nodule to two partially extended intermediate conformers and finally to a fully upright state. Activation of blood platelets by physiological stimuli at sites of vascular injury induces inside-out signaling, resulting in a conformational change of the prototype Integrin alpha IIb beta 3 from an inactive to an active state competent to bind soluble fibrinogen. Furthermore, ligand occupancy of Integrin alpha IIb beta 3 outside-in signaling and additional conformational changes of the receptor, leading to the exposure of extracellular neoepitopes termed ligand-induced binding sites (LIBS), which are recognized by anti-LIBS monoclonal antibodies.
- Shipping Conditions:
- Ambient